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Insect growth regulators (IGRs) are insecticides or compounds that, generally, disrupt the molting process or modify growth and development of insect pests and some mite pests. They don’t directly kill insect pests like contact insecticides, but interfere with the normal mechanisms of development, which results in insect pests dying before they reach adulthood. IGRs typically kill insect pests in three to 10 days; however, the specific IGR, the target insect pest, and life stage may all affect the time required to kill insect pests. IGRs tend to reduce insect pest populations over time — not immediately.
IGRs are classified into three general categories based on their mode of action: juvenile hormone mimics (or analogs), chitin synthesis inhibitors and ecdysone antagonists. Analogs arrest development and cause insect pests to remain in young or immature stages, preventing completion of the life cycle. Chitin synthesis inhibitors interfere with enzymes during the molting process that stimulate the production and formation of chitin, which is an essential component of an insect’s exoskeleton. As such, insect pests fail to reach adulthood because they die in the young stage, or they may mature into sterile adult females. Ecdysone antagonists disrupt the molting process of insect pests by inhibiting metabolism of the molting hormone — ecdysone.
In general, IGRs are directly less harmful to biological control agents than conventional broad-spectrum pest-control materials (insecticides and miticides). However, studies have shown that IGRs may be directly or indirectly harmful to certain natural enemies. The overall effect of IGRs on biological control agents depends on a number of factors, including type of natural enemy (parasitoid or predator), life stage (egg, larva, pupa and adult) sensitivity, rate of application, timing of application, and type and mode of action of IGR used. Another factor to consider is that the harmful effects of IGRs may not be associated with the active ingredient, but due to inert ingredients such as surfactants, adjuvants, carriers or solvents in the formulation.
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